منابع مشابه
“Artifactual” arsenate DNA
The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major...
متن کاملAbsence of detectable arsenate in DNA from arsenate-grown GFAJ-1 cells.
A strain of Halomonas bacteria, GFAJ-1, has been claimed to be able to use arsenate as a nutrient when phosphate is limiting and to specifically incorporate arsenic into its DNA in place of phosphorus. However, we have found that arsenate does not contribute to growth of GFAJ-1 when phosphate is limiting and that DNA purified from cells grown with limiting phosphate and abundant arsenate does n...
متن کاملDifferential expression of microRNAs by arsenate and arsenite stress in natural accessions of rice.
Arsenic (As) contamination of rice (Oryza sativa) imposes a serious threat to human health worldwide. Understanding the molecular mechanisms of As transport and accumulation in rice may provide promising solutions to the problem. MicroRNAs (miRNAs) are a novel class of short, endogenous, non-coding small RNA molecules involved in a wide variety of biological processes such as organ polarity, mo...
متن کاملCultured rat embryo accumulation of DNA, RNA, and protein following maternal administration of sodium arsenate.
Whole embryo culture techniques were used to test the effects of sodium arsenate on the rates of DNA, RNA, and protein accumulation. Rat embryos were isolated on the 10th gestational day (sperm day = Day 0) either 4 or 24 hr after maternal injection. The cultivation period was for 24 or 42 hr. DNA, RNA, and protein values were not significantly different for in utero treatment 4 hr prior to dis...
متن کاملStructural and Functional Consequences of Phosphate–Arsenate Substitutions in Selected Nucleotides: DNA, RNA, and ATP
A recent finding of a bacterial strain (GFAJ-1) that can rely on arsenic instead of phosphorus raised the questions of if and how arsenate can replace phosphate in biomolecules that are essential to sustain cell life. Apart from questions related to chemical stability, there are those of the structural and functional consequences of phosphate-arsenate substitutions in vital nucleotides in GFAJ1...
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ژورنال
عنوان ژورنال: Artificial DNA: PNA & XNA
سال: 2011
ISSN: 1949-095X,1949-0968
DOI: 10.4161/adna.2.1.15657